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The classical cuproptosis inducer, ES-Cu (elesclomol plus copper), increases the protein stability of the transcription factor NFE2L2 (also known as NRF2), leading to the upregulation of gene expression of glutamate-cysteine ligase modifier subunit ( GCLM ) and glutamate-cysteine ligase catalytic subunit ( GCLC )

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hypothesized that the electron-withdrawing phthalimide ring might favor the hydrolysis of the glutarimide ring 155